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These strategic substitutions collectively contribute to improved stability and extended half-life compared to native GHRH while maintaining the natural pulsatile release pattern characteristic of endogenous growth hormone regulation

However, this traditional view has been challenged by evidence from numerous clinical studies [43, 44]

3137 Our group constructed a gene expression profile database of GLP-1R agonists based on geniposide, which was used for treating db/db mice for 11 weeks