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Sacral region or buttock, foot, and scalp are most commonly affected Onset usually in childhood Well-circumscribed gray-blue nodule Localized to reticular dermis Nodular expansile growth patterns of cellular aggregates Often bulging extensions seen at the base of the lesion Biphasic pattern common with combinations of cellular nodules of spindle or epithelioid cells admixed with a background of features of common blue nevus (pigmented spindle and dendritic cells dispersed in a fibrous stroma with melanophages) Alveolar pattern may be present (fascicles of spindle cells compartmentalized by fibrous strands) Monophasic fascicular pattern Melanoma of soft parts (clear cell sarcoma) Primary cutaneous or metastatic melanoma Nerve sheath tumor The plaque-type BN broadly infiltrates dermis and often deeper soft tissue ( Fig

Researchers think that any type of rapid weight loss, including from weight loss drugs like GLP-1s, can lead to muscle loss in addition to fat loss

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