retatrutide phase 2 nejm 2023 obesity trial results Despite substantial weight loss, most drugs such as Wegovy and Mounjaro do not meaningfully improve quality of life and few show cardiovascular benefits at one year, finds a new study in The trial that put “24%”
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The trial that put 24% on the map Retatrutide study sees significant weight loss in obesity drug study Retatrutide: Phase 3 Results (Up to 28.7% Weight Loss), Mechanism, Trials & 2026 Updates Investigational Triple Agonist Among participants 4 to 66 years of age with acquired hypothalamic obesity, setmelanotide, a melanocortin 4 receptor agonist, led to significantly greater reductions in body mass index and hunger than placebo at 52 weeks.
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