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Fifty female Sprague-Dawley rats, weighing 200 20 g and aged eight weeks, were purchased from the Animal House of Shiraz University of Medical Sciences, Shiraz, Iran

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A relevant difference between the DPP-4-resistant GLP-1 RAs and DPP-4 inhibitors is the route of administration: GLP-1 RAs require subcutaneous injection, whereas all DPP-4 inhibitors are oral agents, which may be preferred by patients