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Kim DH, DAlessio DA, Woods SC, Seeley RJ

The chain reaction process of radicalizing cells is known as oxidative damage. When the process takes place, these damaged cells fail to function correctly, and the disfunction compiles to a point where the cells are no longer able to support itself and dies

Indeed, the stronger relationship between elevated circulating homocysteine levels and atherothrombotic disease observed in retrospective case-controlled studies than in prospective studies might be explained by the younger average age of subjects sustaining a coronary event in retrospective studies (in the positive study by Wald et al (1998), see the age comparison between retrospective and prospective studies)