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Eur J Pharmacol 318:429435

Your brain, heart, and muscles shift to burning these ketones as their primary fuel source instead of glucose

Genetic variants including GIPR rs1800437, GLP1R rs6923761, FTO rs9939609, and MC4R rs17782313 relate to the biological pathways these medications act on

Further compounding the problem is the absence of sufficient patient persistence on the drugs: A relatively large portion of patients discontinue these medications within one year , with numbers increasing by the end of years two and three