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Most people experience nothing more than a minor bruising at the injection site, which happens in about 10-15% of treatments

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This suggests that multiple tissues might participate in the oxidation TMA to TMAO

Similar reductions have been observed in other metabolically active tissues-such as the heart, liver, and skeletal muscle-where they may occur either in the context of normal circulating thyroid hormone concentrations, due to tissue-specific alterations in deiodinase activity, or as part of a systemic non-thyroidal illness syndrome (NTIS), in which both serum and tissue T3 levels are reduced despite preserved thyroid gland function [186,187,188]