POGK Rabbit Polyclonal Antibody, 50ul Primary Antibodies SIX2 is a member of

SIX2 is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein

Thr-538 (activation loop of the kinase domain)| Ser-676 (turn motif) and Ser-695 (hydrophobic region)| need to be phosphorylated for its full activation

The encoded protein binds RNA and interacts with two other EJC core components

Mutation analysis of this gene has not revealed any mutation which causes the CPX disorder

POGK Rabbit Polyclonal Antibody, 50ul Primary Antibodies SIX2 is a member ofThe exact function of the protein encoded by this gene is not known. However this gene product contains a KRAB domain (which is involved in protein protein interactions) at the N terminus and a transposase domain at the C terminus suggesting that it may belong to the family of DNA mediated transposons in human.