Rac GAP1(Phospho Ser387) Polyclonal Antibody, 20ul DNA/RNA Isolation & Purification Overexpression of PTK6 in mammary

Overexpression of PTK6 in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype

This gene encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family

the level of this protein in plasma increases greatly during acute phase response to tissue injury

Constitutive activation of this gene caused either by somatic mutations| or genomic duplications of regions that include this gene| have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome

Rac GAP1(Phospho Ser387) Polyclonal Antibody, 20ul DNA/RNA Isolation & Purification Overexpression of PTK6 in mammaryThis gene encodes a GTPase activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on