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Metformin may be considered for patients with metabolic complications due to its potential to inhibit hypoxia-induced fibrosis in adipose tissue.40 Oral analgesics may be used for pain management, although systematic data on pharmacological therapies are lacking.8 Despite its association with sex hormones, there is no scientific basis for the use of estrogens, progestins, testosterone, or hormonal implants in the treatment of lipedema

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Tracking non-scale victoriessuch as reduced cravings, improved portion control, how your clothes fit, and healthy habits like staying hydrated and meeting your protein goalscan provide a more complete picture of your progress in the first month

Some practitioners prescribe ursodeoxycholic acid prophylactically during aggressive weight loss to reduce gallstone risk