CHR-6494 - CAS# 1333377-65-3 Catalog No.:M10283-2 The deleterious synergistic effect between

The deleterious synergistic effect between ER-stress and ISRIB may be generally advantageous to kill cancer cells

The high dose for both MLN2238 and Bortezomib shows similar antitumor activity in this model (T/C=0

It has no effect on a panel of seven other methyltransferases

providing biochemical evidence of NMDA receptor antagonism in vivo

CHR-6494 - CAS# 1333377-65-3 Catalog No.:M10283-2 The deleterious synergistic effect betweenCHR 6494 is a potent and selective histone kinase Haspin inhibitor. CHR 6494 reduces H3T3ph levels in a dose dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. CHR 6494 shows antitumor potential in xenografted nude mice without any observed toxicity. Thus, CHR 6494 is a first in class Haspin inhibitor with a wide spectrum of anticancer effects that merits