D-Sphingosine - CAS# 123-78-4 Catalog No.:M6801-2 In several hypertension rat models

In several hypertension rat models

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D-Sphingosine - CAS# 123-78-4 Catalog No.:M6801-2 In several hypertension rat modelsD Sphingosine, CAS No. 123 78 4, is formed primarily from the breakdown of ceramide. Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase. D sphingosine, a lipid possessing the same hydrophobic base as ceramide but without a carbohydrate residue, efficiently blocked this glycolipid antigen presentation both in vitro and in spinal cords of EAE mice, and significantly decreased IL 17 and ameliorated the pathological symptoms.