Nav1.7-IN-1 Size:Solid 10 mg Chemical Name: MK-8776 S-isomer

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Nav1.7-IN-1 Size:Solid 10 mg Chemical Name: MK-8776 S-isomerPF 05089771 is a Selective Nav1. 7 Inhibitor (IC50 = 11 nM) that interacts with the voltage sensor domain (VSD) of domain IV. PF 05089771 exhibits a slow onset of block that is depolarization and concentration dependent, with a similarly slow recovery from block. Human hereditary gain or loss of pain disorders have demonstrated an essential role of Nav1. 7 sodium channels in the sensation of pain, thus making this channel an attractive target for new

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