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ML-329 - CAS# 19992-50-8 072 Aticaprant (CERC-501) shows no appreciable

ML-329 - CAS# 19992-50-8 072 Aticaprant (CERC-501) shows no appreciable

Name: ML-329 - CAS# 19992-50-8 072 Aticaprant (CERC-501) shows no appreciable
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ML-329 - CAS# 19992-50-8 072 Aticaprant (CERC-501) shows no appreciableML 329, CAS No. 19992 50 8, is an inhibitor of the microphthalmia associated transcription factor (MITF) pathway with an IC50 value of 1. 2 M for promoter activity of the MITF target gene TRPM 1. ML 329 showed specific activity against the MITF dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML 329 reduced the expression of multiple MITF target genes, including pigment related genes and the cell cycle regulator CDK2.

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Description

Aticaprant (CERC-501) shows no appreciable affinity for several non-opioid cell surface G-protein-coupled receptor targets

Bolhassani M

CAS Number: 524684-52-4

CAS Number: 1638250-96-0

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