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Semaglutide followed in the 2010s, initially for diabetes and later approved for weight loss based on landmark STEP trials showing up to 22% body weight reduction

On effectiveness, injections generally produce greater and more consistent results, while oral GLP-1 can be effective but with more variability

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Regulatory mechanisms of the gut microbiota-short chain fatty acids signaling axis in slow transit constipation and progress in multi-target interventions