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LPS administration induced an APR and consequently IL-6 responded strongly to the immune challenge with an increase to a maximum at 3 h pi followed by a decrease to the baseline until 24 h pi

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It is thought to be triggered by prolonged stress and likely has a strong genetic component

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[DOI] [PubMed] [Google Scholar] [80].Ohta H, Sunden Y, Yokoyama N, Osuga T, Lim SY, Tamura Y, et al

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