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GW 5074 - CAS# 220904-83-6 Catalog No.:M10941-10 InChi: InChI=1S/C19H19N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-21-17)15(27)10-20-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9

GW 5074 - CAS# 220904-83-6 Catalog No.:M10941-10 InChi: InChI=1S/C19H19N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-21-17)15(27)10-20-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9

Name: GW 5074 - CAS# 220904-83-6 Catalog No.:M10941-10 InChi: InChI=1S/C19H19N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-21-17)15(27)10-20-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9
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GW 5074 - CAS# 220904-83-6 Catalog No.:M10941-10 InChi: InChI=1S/C19H19N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-21-17)15(27)10-20-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9GW5074 is a c Raf inhibitor. GW5074 has no direct effect on the activities of several apoptosis associated kinases when assayed in vitro. In contrast to its effect in vitro, treatment of neurons with GW5074 causes c Raf activation (when measured in vitro in the absence of the drug) and stimulates the Raf MEK ERK pathway. GW5074 prevents neurodegeneration and improves behavioral outcome in an animal model of Huntington's disease. GW5074 could have

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InChi: InChI=1S/C19H19N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-21-17)15(27)10-20-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9

Yagishita S

Smiles: COCCOC1C=CC(=CC=1)NC1=NC(NC2=CC(=CC=C2)NC(=O)C=C)=C(F)C=N1

likely at the 5-HT2A

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