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TMP269 - Class IIa HDAC Inhibitor. CAS# 1314890-29-3 size:10mg solid 149(5):1060-1072

TMP269 - Class IIa HDAC Inhibitor. CAS# 1314890-29-3 size:10mg solid 149(5):1060-1072

Name: TMP269 - Class IIa HDAC Inhibitor. CAS# 1314890-29-3 size:10mg solid 149(5):1060-1072
Brand: gspetersdorf.de
SKU: 67135364337
Price: 120.00 USD
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SKU: 67135364337

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TMP269 - Class IIa HDAC Inhibitor. CAS# 1314890-29-3 size:10mg solid 149(5):1060-1072TMP269, CAS No. 1314890 29 3, is a highly potent, selective and cell permeable class IIa HDAC inhibitor with IC50 of 126 nM, 80 nM, 36 nM and 19 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. It has very weak or no activity targeting the other HDACs (2 40 M). TMP269 has an unprecedented metal binding group, trifluoromethyloxadiazole (TFMO), which circumvents the selectivity and pharmacologic liabilities of hydroxamates. Crystallography revealed a

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Description

149(5):1060-1072

4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide

Significant rates of apoptosis are seen in all models that had been treated with combination GSK2256098 and Paclitaxel

InChiKey: VXNYQUQHOUERTR-UHFFFAOYSA-N

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