Clofarabine nine TG100-115 inhibits PI3Kγ and PI3Kδ

TG100-115 inhibits PI3Kγ and PI3Kδ with IC50s of 83 and 235 nM

2016 Jan 6

InChiKey: OVDSPTSBIQCAIN-UHFFFAOYSA-N

Cilnidipine is the novel calcium antagonist accompanied with L-type and N-type calcium channel blocking function

Clofarabine nine TG100-115 inhibits PI3Kγ and PI3KδClofarabine is a second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5' triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of