AM966 Size:Solid 10 mg KW-2449 mediates cytotoxicity thru inhibition
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AM966 Size:Solid 10 mg KW-2449 mediates cytotoxicity thru inhibitionAM966 is a potent, selective, and orally active LPA(1) receptor antagonist which inhibits lung fibrosis in the mouse bleomycin model. In vitro, AM966 inhibited LPA stimulated intracellular calcium release from Chinese hamster ovary cells stably expressing human LPA(1) receptors and inhibited LPA induced chemotaxis of human IMR 90 lung fibroblasts expressing LPA(1) receptors. AM966 reduced lung injury, vascular leakage, inflammation and fibrosis at
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