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A nested case-control study analyzed data from the French national health care insurance system (SNDS) on individuals with T2D treated with second-line anti-diabetes drugs from 2006 to 2018, reported an increased risk of all thyroid cancer and medullary thyroid cancer with use of GLP-1 agonists after 13 years of treatment 47

Multiple hypothesised mechanisms by which GIP RA perform synergistically with GLP-1RA are described: (1) activation of hypothalamic GIPR+ cells reduces food intake

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This is a localised and transient chemical response, not an allergic reaction and not a sign of peptide instability