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Concentration adjustment proves essential with under-eye products requiring 30-50% lower active concentrations than facial formulations to prevent irritation - while 1-2% GHK-Cu works well on face , 0.5-1% proves safer for eye area maintaining effectiveness while minimizing redness or stinging risks

It can also be a quality signal if reactions are unusually intense or persistent

Immunofluorescence staining in LO2 cells displayed that PPAR- all located in the nucleus and PGPIPN up-regulated PPAR- level (Figure 9), as the same as that in western blotting